Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3023 | 3023-30304 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74V, V75T, L210W, T215Y | K219Q | L100I, K103N | T39K, K43E, K65KE, K122E, I135T, V179I, I202V, E203D, R211Q, D218E, L228H |
| >3023-30304| codons 38-247 CKELEEEGKISKIGPENPYNTPVFAIKEKNSTRWRKVTDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYMDDLYVGSDLEIGQHRTKVDELRQHLWQWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33F | E35D, M36I, N37D, R41RK, L63P, A71V, I72IT, T91TS, Q92QK | G40GE, I93P |
| >3023-30304| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVFEDIDLPEKWKPKLIGGIGGFVKVRQYDQIP IEICGHKVTGTVLVGPTPANIIGRNLMSKPGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |