<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3023 3023-30304 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74V, V75T, L210W, T215Y K219Q L100I, K103N   T39K, K43E, K65KE, K122E, I135T, V179I, I202V, E203D, R211Q, D218E, L228H  
>3023-30304| codons 38-247
CKELEEEGKISKIGPENPYNTPVFAIKEKNSTRWRKVTDFRELNKRTQDFWEVQLGIPHP
AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIIIYQYMDDLYVGSDLEIGQHRTKVDELRQHLWQWGFYTP
EQKHQKEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L10F, L33F E35D, M36I, N37D, R41RK, L63P, A71V, I72IT, T91TS, Q92QK G40GE, I93P
>3023-30304| codons 4-99
TLWQRPFVTIKIGGQLKEALLDTGADDTVFEDIDLPEKWKPKLIGGIGGFVKVRQYDQIP
IEICGHKVTGTVLVGPTPANIIGRNLMSKPGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006