Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3021 | 3021-30303 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F | I13V, I15V, K20T, E35D, M36I, I72V, L89I |
| >3021-30303| codons 4-99 TLWQRPFVTVKVGGQLTEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYDQIL IEICGHKAVGTVLVGPTPVNVIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215F | K219Q | V60I, T69N, K101Q, V118VI, K122E, I135T, K166KR, Q197P, T200A, H208Y, R211K, D218E |
| >3021-30303| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSNKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIGPHRAKIEELRQYLLKWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |