Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3112 | 3112-30529 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T | L24I | L10I, K20KR, E35D, M36L, N37D, K55R, I62V, L63P, I64V, T74S |
| >3112-30529| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVLEDLDLPGRWKPKIIGGIGGFVRVRQYDQVP VEICGHKAIGSVLVGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184V, T215F | K219Q | Y181C, G190S | K101H | T39A, V60VI, V118I, K122E, S162D, E169D, V179I, R211K, F214L, D218E, L228H, Q242QH | I159L |
| >3112-30529| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP ALFQDSMTKILDPFRKQNPDIIICQYVDDLYVSSDLEIGQHRTKIEELRQHLLKWGLFTP EQKHQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |