Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3109 | 3109-30514 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69TADN, L74V, M184V, L210W, T215Y | Y181C | K43N, E44D, K101Q, K122E, G190X, G196E, E203EK, R211RK, K223Q |
| >3109-30514| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVXSDLEIEQHRTKIKELRQHLWKWGFYTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | G73S | L10I, I15V, Q18QH, K20I, L24LF, E35D, M36I, N37E, R41K, L63P, A71V, I72IL |
| >3109-30514| codons 4-99 TLWQRPIVTIKVGGHLIEALFDTGADDTVLEDIELPGKWKPKIIGGIGGFVKVRQYDQIP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |