Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3066 | 3066-30407 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K101P, K103S | T39A, E44D, A98S, V118I, D123E, D177N, I178M, V179VI, G196GE, T200A, E203K, H208Y, R211K, W212C, K223Q | N54I |
| >3066-30407| codons 38-247 CAELEKDGKISKIGPEIPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP SGLPKSKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPNMIIYQYVDDLYVGSDLEIEQHRAKIKELRQYLWKCGFYTP DNKHQQEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11VI, Q58E, G73T | L19IT, K20I, M36I, I62V, L63C, I64IV, H69R, A71V, V77VI, I93L |
| >3066-30407| codons 4-99 TLWQRPFITIKIGGQTIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYDQVC VEICGRKVITTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |