<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3066 3066-30407 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11VI, Q58E, G73T L19IT, K20I, M36I, I62V, L63C, I64IV, H69R, A71V, V77VI, I93L  
>3066-30407| codons 4-99
TLWQRPFITIKIGGQTIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYDQVC
VEICGRKVITTVLIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M, K219N K101P, K103S   T39A, E44D, A98S, V118I, D123E, D177N, I178M, V179VI, G196GE, T200A, E203K, H208Y, R211K, W212C, K223Q N54I
>3066-30407| codons 38-247
CAELEKDGKISKIGPEIPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
SGLPKSKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPNMIIYQYVDDLYVGSDLEIEQHRAKIKELRQYLWKCGFYTP
DNKHQQEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006