Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3062 | 3062-30324 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | L10FI, V11I, G73S | T12TKPQ, I15V, G16A, L19P, K20I, E21ED, M36I, L63P, A71V, I72IM, I85V |
| >3062-30324| codons 4-99 TLWQRPIIQIKVAGQPIDALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQIP IEICGHKVMSTVLVGPTPTNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | Y188L | V179E | T39TA, E44D, K49R, V106I, L109LI, V118I, K122E, I135T, T139I, K166Q, E169D, P170L, R211RK, D218E, K223Q |
| >3062-30324| codons 38-247 CAELEKDGKISRIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVIDVGDAYFSIPLDEDFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSP AIFQSSMTQILDLFRKQNPDIEIYQYVDDLLVGSDLEIGQHRTKIEELRQHLWKWGFYTP EKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |