Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3042 | 3042-30313 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | Q58E | L10I, I13V, I15V, G16A, K20T, D60E, Q61D, L63P, I64V, I66F, A71T, I72T, T91A, I93V | L97M |
| >3042-30313| codons 4-98 TLWQRPIVTVKVAGQLTEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVREYEDIP VEFCGHKTTGTVLVGPTPVNVIGRNLMAQVGCTMN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K103KN | V60I, K104KR, V118I, K122E, I135T, Q174H, G196E, F214L |
| >3042-30313| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNRSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKHNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |