Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3035 | 3035-30310 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | Y188L | A98G | K64KR, K122KE, D123E, D177E, V179C, R211K |
| >3035-30310| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIRKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEICIYQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L23I, F53FL | L10I, N37NS, R41RK, D60E, I62V, L63P, I64L, A71T, I72IV, V77I, I93L |
| >3035-30310| codons 4-99 TLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMSLPGKWKPKMIGGIGGLVKVRQYEQVP LEICGHKTVGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |