Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3031 | 3031-30303 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DN, K70R, L74I, T215F | V75S, K219Q | G190Q | V179D | A98S, K122E, I135T, Q174QK, T200A, I202V, Q207A, R211A, L228H |
| >3031-30303| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKISDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDIDIYQYMDDLYVQSDLEIGQHRAKVEELRAHLLAWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | L10F, V11I, G73S | T4TP, I13V, I15V, K20I, E35NS, M36I, R41K, D60DE, I62V, L63P, A71T, I72L |
| >3031-30303| codons 4-99 PLWQRPFITVKVGGQLIEALLDTGADDTVLESINLPGKWKPKIIGGIGGFVKVRQYEQVP IEICGHKTLSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |