Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3068 | 3068-30724 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10FI, G73S | T12A, I13V, I62V, L63P, I64V, A71T, I72T, V77I, I93L, C95F |
| >3068-30724| codons 4-99 TLWQRPIVAVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYDQVP VEICGHKTTSTVLIGPTPVNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74LI, M184V, T215F | V75VA, K219E | K103N | V108I | V60I, T69N, A98S, K101Q, V118I, K122E, I135V, Q174K, T200A, I202V, R211K, L228H, Q242H | K64KHNQ, T216L |
| >3068-30724| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIQKKNSNRWRKIADFRELNKRTQDFWEVQLGIPHP SGLQKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDIVIYQYVDDLYVGSDLEIGQHRAKVEELRQHLLKWGFFLP DEKHQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |