Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3187 | 3187-30623 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82T, I84V | L24I, L33F | L10I, I13V, L63P, I64V |
| >3187-30623| codons 4-99 TLWQRPIVTVKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP VEICGHKAIGTVVVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74LV, M184MV, T215FI | K219E | K103KN | V60I, T69N, A98S, V118VI, K122E, I142IV, F214L, L228LH, V245M |
| >3187-30623| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLITP DEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |