Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3174 | 3174-30812 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215F | Y188L | K43E, V118I, K122KE, I135V, S162C, D177E, V179VI, G196E, T200A, Q207H, R211K, V245I | D113DN |
| >3174-30812| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGNAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIIIYQYVDDLLVGSDLEIEQHRAKIEELRHHLLKWGFFTP DKKHQKEPPFLWMGYELHPDKWTVQPIILP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I, L33F, F53L | L10I, K20T, R41K, L63P, A71V, I93L |
| >3174-30812| codons 4-99 TLWQRPIVTIKIGGQLTEALIDTGADDTVFEEMNLPGKWKPKMIMGIGGLVKVRQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |