Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3128 | 3128-30514 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10FI, L33LF, G73T | L19LI, E34EQ, G51GA, K55R, R57RK, I62V, L63P, I66IV, A71AV, V77VI |
| >3128-30514| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKIIGGIAGFVRVKQYDQVP IEVCGHKVITTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K103N, G190A | K43Q, E44D, V118I, K122E, D123N, K166R, G196E, T200A, Q207E, R211K, I244IV, V245E | K102KNRS, Q197V |
| >3128-30514| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKSNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVIYQYVDDLYVASDLEIEVHRAKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPVELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |