Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3129 | 3129-30514 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | I13V, I15V, Q18I, K20IV, M36MI, D60E, I62V, L63P, A71V, I72FL |
| >3129-30514| codons 4-99 TLWQRPFVTVKVGGILVEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYEQVP IEICGHKVLSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75VA, K219N | K43E, E44D, V118I, D121H, K122E, I135T, S162Y, D177G, V179VI, H208Y, D218E, V245K |
| >3129-30514| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKLADFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPGIIIYQYVDDLYVGSDLEIGQHRTKIEELRQYLWRWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |