Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3182 | 3182-30514 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L33F, K43T | T12I, I13V, K20R, E35D, M36I, N37D, R57RK, Q61DE, I62V, L63P, I64V, A71V, I93L |
| >3182-30514| codons 4-99 TLWQRPLVIVKIGGQLREALLDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVKQYDEVP VEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | K70T, V75A | Y181C, G190A | V60I, S68G, K73M, K122E, D123DN, I135IT, S162D, T165I, Q174H, T200A, Q207E, R211K, F214L, H221Y, H235HR |
| >3182-30514| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKRKDGTTWRMLADFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMIKILEPFRKHNPDIVICQYMDDLYVASDLEIGQHRAKIEELREHLLKWGLTTP DKKYQKEPPFLWMGYELRPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |