<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3094 3094-30509 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Q151M, M184V V75I, F77L, F116Y Y181YFIN, G190A V179D T39A, S68G, K103R, K122E, T139KR, I142T, K173KR, Q174H, V189I, I195IL, R211K, F214L, D218DE, V245KM T69V
>3094-30509| codons 38-247
CAEMEKEGKISKIGPENPYNTPVFAIKRKDGVRWRKLIDLRELNKRTQDFWEVQLGIPHP
AGLKKRKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNERPGTRYQYNVLPMGWKGSP
AIFQSSMTKILEPFRRHNPDIDINQYVDDLYIASDLELGQHRTKIEELRQHLLKWGLTTP
EKKHQKEPPFLWMGYELHPDKWTVQPIMLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, Q58E, G73S V11L, I13V, K14R, I15V, K20I, M36I, R41K, D60E, I62V, L63P, A71V, I72L, I85IV  
>3094-30509| codons 4-99
TLWQRPFLTVRVGGQLIEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFVKVREYEQVP
IEICGHKVLSTVLVGPTPVNVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006