Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3094 | 3094-30509 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, Q58E, G73S | V11L, I13V, K14R, I15V, K20I, M36I, R41K, D60E, I62V, L63P, A71V, I72L, I85IV |
| >3094-30509| codons 4-99 TLWQRPFLTVRVGGQLIEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFVKVREYEQVP IEICGHKVLSTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M, M184V | V75I, F77L, F116Y | Y181YFIN, G190A | V179D | T39A, S68G, K103R, K122E, T139KR, I142T, K173KR, Q174H, V189I, I195IL, R211K, F214L, D218DE, V245KM | T69V |
| >3094-30509| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKRKDGVRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNERPGTRYQYNVLPMGWKGSP AIFQSSMTKILEPFRRHNPDIDINQYVDDLYIASDLELGQHRTKIEELRQHLLKWGLTTP EKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |