<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3092 3092-30506 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, M184V, L210W, T215Y   V106A V108I, F227L T39A, K43E, E44A, V60I, V118I, K122E, I142V, D177E, I178L, G196GE, T200A, E203V, Q207E, H208Y, R211K, K223E, E224EK, V245E  
>3092-30506| codons 38-247
CAELEEAGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSATILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPELVIYQYVDDLYVGSDLEIEQHRAKIVELREYLWKWGFYTP
DKKHQEKPPLLWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, V11VI, G73T I15V, K20V, M36I, R41K, I62IV, L63P, A71V, I85V, I93L  
>3092-30506| codons 4-99
TLWQRPFITIKVGGQLVEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFVKVRQYDQVP
IEICGHKVITTVLVGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006