<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3091 3091-30501 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, I84V, L90M V11I, F53L, G73C, L89LV W6C, L10I, I13V, I15V, K20I, M36I, N37ND, K55KR, R57RK, I62V, L63P, I64V, T74S, V82X, T91TS  
>3091-30501| codons 4-99
TLCQRPIITVKVGGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGLVRVKQYDQVP
VEICGHKAICSVLVGPTPXNVIGRNVMSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KE, L74LV, M184V, L210W, T215Y K219R L100LI, K103KN V108VI T39TA, E44D, V75X, V118I, K122E, I135IT, S162CDGY, V179VA, G196GE, T200TA, Q207QE, R211RK, D218E, L228H  
>3091-30501| codons 38-247
CAELEKDGKISKIGPENPYNTPVFAIKKKNSTEWRKVXDFRELNKRTQDFWEVQLGIPHP
AGIKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDIAIYQYVDDLYVGSDLEIEQHRAKIEELREHLWKWGFYTP
ERKHQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006