Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3091 | 3091-30501 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | V11I, F53L, G73C, L89LV | W6C, L10I, I13V, I15V, K20I, M36I, N37ND, K55KR, R57RK, I62V, L63P, I64V, T74S, V82X, T91TS |
| >3091-30501| codons 4-99 TLCQRPIITVKVGGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGLVRVKQYDQVP VEICGHKAICSVLVGPTPXNVIGRNVMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KE, L74LV, M184V, L210W, T215Y | K219R | L100LI, K103KN | V108VI | T39TA, E44D, V75X, V118I, K122E, I135IT, S162CDGY, V179VA, G196GE, T200TA, Q207QE, R211RK, D218E, L228H |
| >3091-30501| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTEWRKVXDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIAIYQYVDDLYVGSDLEIEQHRAKIEELREHLWKWGFYTP ERKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |