Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3089 | 3089-30430 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48MV, I54T, V82A, I84V | L33LF, K43T | L10I, K20R, E34R, E35D, M36I, I62IV, L63P, A71V, I72V, V77I, I93L |
| >3089-30430| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFRDINLPGRWTPKMIVGIGGFTKVRQYDQVP IEICGHKVVGTVLIGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | T39TA, K43KN, K122E, I135V, I142V, S162C, K173KE, Q174QE, D177E, T200A, L210F, R211RK, L228H, I244V |
| >3089-30430| codons 38-247 CAELENEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQCSMTKILEPFREENPEIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLFKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |