Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3087 | 3087-30417 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, L210W, T215F | K219Q | A98G | E44ED, V60I, D123E, I135T, S162Y, G196K, T200I, E203D, Q207E, H208Y, R211K, E224D, L228H, Q242H |
| >3087-30417| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIKQHRIKIDELREYLWKWGFFTP DQKHQKDPPFHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A, L90M | F53L, Q58E, G73S | L10I, T12I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, I72IMT |
| >3087-30417| codons 4-99 TLWQRPIVIVKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIMGIGGLVKVREYDQVP IEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |