Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3199 | 3199-30716 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, V82T, L90M | L10I, I15V, L19I, K20R, E35D, M36I, R41K, R57K, I62V, L63P, I72M, T74S, I93L |
| >3199-30716| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTVLEDINLPGKWKPKIIVGIGGFIKVKQYDQVP IEICGHKAMGSVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | G190S | K43KDEN, E44D, K166R, V179I, T200TA, R211K, V245MT |
| >3199-30716| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIIIYQYVDDLYVSSDLEIGQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |