Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3013 | 3013-30402 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A | Q58E | L10I, I15V, K20R, E35D, M36I, D60E, I62V, L63P, A71V, P79A, I93L |
| >3013-30402| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEDINLPGRWKPKMIVGIGGFSKVREYEQVP IEICGHKVIGTVLVGATPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | F77L, K219KR | K103N | K43Q, E44D, V118I, K122E, I135L, S162D, K166R, G196E, R211K, L228H, Q242H, V245M |
| >3013-30402| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKDSDKWRKLMDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQDSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DRKHQKEPPFHWMGYELHPDKWTVHPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |