Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3010 | 3010-30716 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F | T12P, I13V, K20I, E35D, M36I, N37ND, I62V, L63P, I64V, T74S |
| >3010-30716| codons 4-99 TLWQRPFVPVKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYDQVP VEICGHKAIGSVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184MV | A62V, V75I, F77FL, F116Y, T215V, K219Q | K101P, Y181C | K64R, S68R, V90VI, L109LM, V118I, K122E, I135T, K173N, V179I, I202V, R211K, F214L, H221HY, L228LH |
| >3010-30716| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIRRKDRTKWRKLIDLRELNKRTQDFWEIQLGIPHP AGLPKKKSVTVMDVGDAFYSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRNQNPDIIICQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLVTP DQKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |