Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3008 | 3008-30224 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, N37D, K55R, I62V, L63P, I64L, A71T, I72V, V77I, I93L, C95F |
| >3008-30224| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIGGIGGFVRVRQYDQVP LEICGHKTVGTVLIGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67N, Q151M | A62AV, V75I, F116Y, T215V, K219Q | Y181C | V108I | T39A, I94L, K101Q, K102KQ, G112A, D123E, T139A, A158S, S162D, K166R, D177E, V189I, H208Y, R211K, D218E, L228H, P243PS, V245MT | S68SDGN |
| >3008-30224| codons 38-247 CAELEKEGKISKIGPENPYNTPVFVIKRKNNTKWRKLIDFRELNKRTQDFWEVQLGLPHP AGLQQKKSVTILDVADAYYSVPLDKEFRKYTAFTIPSINNEAPGIRYQYNVLPMGWKGSP SIFQDSMTRILEPFRKQNPEIVICQYMDDLYIGSDLEIGQHRTKIEELRQYLLKWGFVTP EQKHQKEPPFHWMGYELHPDKWTVQSITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |