Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3007 | 3007-30224 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219D | A98G | T39R, K43E, E44ED, K49KR, V60I, S68SG, R83K, I94L, V118I, K122E, V179I, G196E, T200A, H208Y, R211K, D218E, V245E | L228HY |
| >3007-30224| codons 38-247 CRELEEDGKISRIGPENPYNTPIFAIKKKNGTKWRKLMDFRELNKKTQDFWEVQLGLPHP GGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTP EDKHQKEPPFYWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, Q58E, G73T | T4TA, I13V, K14KIMN, K20R, E35D, M36I, N37D, K55KR, R57RK, D60DE, I62V, L63P, A71V, I85V, I93L |
| >3007-30224| codons 4-99 ALWQRPFVTVNIGGQLREALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVRVKEYEQVP IEICGHKVITTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |