<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3007 3007-30224 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M, K219D   A98G T39R, K43E, E44ED, K49KR, V60I, S68SG, R83K, I94L, V118I, K122E, V179I, G196E, T200A, H208Y, R211K, D218E, V245E L228HY
>3007-30224| codons 38-247
CRELEEDGKISRIGPENPYNTPIFAIKKKNGTKWRKLMDFRELNKKTQDFWEVQLGLPHP
GGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTP
EDKHQKEPPFYWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F, Q58E, G73T T4TA, I13V, K14KIMN, K20R, E35D, M36I, N37D, K55KR, R57RK, D60DE, I62V, L63P, A71V, I85V, I93L  
>3007-30224| codons 4-99
ALWQRPFVTVNIGGQLREALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFVRVKEYEQVP
IEICGHKVITTVLVGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006