Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3002 | 3002-30219 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A, L90M | F53L | L10I, T12Q, I15V, L19P, K20M, E35ED, M36IV, R41K, I62V, L63P, A71I, T74S, I93L |
| >3002-30219| codons 4-99 TLWQRPIVQIKVGGQPMEALLDTGADDTVLEDVNLPGKWKPKMIMGIGGLVKVRQYDQVP IEICGHKIIGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V, T215Y | K103N, Y181C | T39A, S68G, K122E, D123E, I135T, S162C, D177DN, G196E, T200TI, I202IV, R211T, V245T | N54I |
| >3002-30219| codons 38-247 CAEMEKEGKISKIGPEIPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFFSVPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPNIVICQYVDDLYVGSDLEIEQHRIKVEELRQHLLTWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |