Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3001 | 3001-30219 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82C, L90M | L10F, L33F, G73C | T12E, G16A, L19I, N37T, R41RK, L63P, I64V, I72L, I93L |
| >3001-30219| codons 4-99 TLWQRPFVEIKIAGQIKEALLDTGADDTIFEEMTLPGKWKPKIVGGIGGFLKVRQYDQIP VEICGHKALCTVLVGPTPCNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70KEGR, L74I, V75M, M184V, L210W, T215F | D67S, K219Q | K103N | T69N, V118I, K122E, I135L, S162D, T200A, Q207E, D218E, L228H |
| >3001-30219| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKSSNRWRKIMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELREHLWRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |