Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3004 | 3004-30716 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I47IV, G48V, I54V, V82A, L90M | Q58E | L10I, I15V, L19I, K20R, E35D, M36I, N37D, I62V, L63V, I72V, T74S, I85IV, L89M |
| >3004-30716| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTVLEDIDLPGRWKPKLVVGIGGFVKVREYDQVV IEICGHKAVGSVLVGPTPANIVGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | Y181C, G190A | E44D, T69N, K101KQ, V118I, D121H, K122E, D177E, E203D, H208Y, R211K, L228H |
| >3004-30716| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVASDLEIGQHRTKIDELRQYLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |