Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3158 | 3158-30529 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210*SW, T215Y | D67G, K219Q | K101KE, G190A | E44D, V60I, S68G, K103R, V118I, K122E, D123N, I135T, S162SDGN, E194EK, H208HY, D218E, D237DE, V245E |
| >3158-30529| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKRKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYVDDLYVASDLKIGQHRTKIEELRQYLWRWGFYTP EQKHQKEPPFLWMGYELHPEKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I62V, L63P, I64V, I66IV, A71T, I72V, V77VI |
| >3158-30529| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYDQVP VEVCGHKTVTTVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |