Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3124 | 3124-30428 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | V11I, G73S | L10I, T12P, K14R, E35D, N37D, K45R, L63P, A71V, I72L, V77VI, I93L |
| >3124-30428| codons 4-99 TLWQRPIIPIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPRIIGGIGGFVKVRQYDQIP IEICGHKVLSTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, T215F | K219Q | K101E, K103N | T39A, V60I, A98S, K122E, I135T, E138A, I142V, T200A, D218E, V245T |
| >3124-30428| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP SGLEKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNATPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |