Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3123 | 3123-30425 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LV, V75AT, M184V, L210LW, T215F | K219E | Y181C | K43Q, V60VI, T69N, K101KQ, K102KE, V118VI, K122E, I135T, I167IV, H208Y, W212WLMR, D218E, K223KQ, L228H, Q242QH |
| >3123-30425| codons 38-247 CTELEQEGKISKIGPENPYNTPIFAIKKKNSNRWRKVTDFRELNKRTQDFWEVQLGIPHP AGLQEKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELRQYLWRRGFFTP EEKHQQEPPFHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, L90M | L10I, T12TP, I13V, I15IV, G16GA, K20IT, E35D, M36I, I62V, L63P, A71V, V82I, I93L |
| >3123-30425| codons 4-99 TLWQRPIVPVKVAGQLTEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFMKVRQYDQVP IEICGHKVIGTVVVGPTPINIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |