<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3123 3123-30425 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L76V, L90M   L10I, T12TP, I13V, I15IV, G16GA, K20IT, E35D, M36I, I62V, L63P, A71V, V82I, I93L  
>3123-30425| codons 4-99
TLWQRPIVPVKVAGQLTEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFMKVRQYDQVP
IEICGHKVIGTVVVGPTPINIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74LV, V75AT, M184V, L210LW, T215F K219E Y181C   K43Q, V60VI, T69N, K101KQ, K102KE, V118VI, K122E, I135T, I167IV, H208Y, D218E, K223KQ, L228H, Q242QH W212WLMR
>3123-30425| codons 38-247
CTELEQEGKISKIGPENPYNTPIFAIKKKNSNRWRKVTDFRELNKRTQDFWEVQLGIPHP
AGLQEKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKVLEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELRQYLWRRGFFTP
EEKHQQEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006