Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3122 | 3122-30423 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L10F, G73T | K14R, K20I, M36I, L63P, I64V, I72IV, I93L |
| >3122-30423| codons 4-99 TLWQRPFVTIRIGGQLIEALLDTGADDTILEEINLPGRWKPKIVGGIGGFIKVRQYDQIP VEICGHKAVTTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | Y181YC | K43KE, V90VI, S117SA, K122E, I135T, I142IT, S162Y, Q174QH, Q207QAEP, H208HY, R211RK, L228R | N57H |
| >3122-30423| codons 38-247 CTELEEEGKISKIGPENPYHTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFAVPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKHNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRPYLLKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |