Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3121 | 3121-30422 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K43E, V90I, V118I, D123E, I142V, I178M, E203D, Q207K, H208Y, R211K |
| >3121-30422| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRTKIDELRKYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, G73S | I13IV, I15V, K20I, E35D, M36I, N37E, D60E, L63P, A71V, I93L | V11Y |
| >3121-30422| codons 4-99 TLWQRPLYTVKVGGQLIEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVREYEQIP IEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |