Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3061 | 3061-30416 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | F53L | L10I, G16E, K20R, M36I, L38LF, P39S, I62V, L63P, A71V, I72V | D29V |
| >3061-30416| codons 4-99 TLWQRPIVTIKIEGQLREALLDTGAVDTVLEEINFSGRWKPKIIGGIGGLVKVRQYDQVP IEICGHKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210LW | K103N | T69S, K122E, T139K, D177E, I178L, R211K, F214L |
| >3061-30416| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |