Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3117 | 3117-30416 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | L19I, K55R, D60E, Q61QH, I62IV, L63P, I64V, I66V, V77VI, P79A |
| >3117-30416| codons 4-99 TLWQRPFVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVRQYEHVP VEVCGHKAITTVLIGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, V75T, M184V, T215F | K219Q | L100I, K103N | T39A, T69N, K122E, I135M, S162SG, D177DN, G196E, I202IV, H208Y, D218E, L228H, V245M |
| >3117-30416| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQGSMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIEQHRTKVEELRQYLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |