Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3060 | 3060-30415 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, L33F, N83D, N88D | T4S, I13V, G16A, L19I, E35N, M36I, P39S, I62V, L63P, A71V, I72V | L24L* |
| >3060-30415| codons 4-99 SLWQRPFVTVKIAGQIKEAL*DTGADDTVFENINLSGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKVVGTVLVGPTPVDVIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | V108I | T39A, E44D, V60I, V118I, K122E, I135T, E203K, Q207E, H208F, R211RK, K223Q |
| >3060-30415| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIKELREFLWKWGFYTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |