Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3057 | 3057-30407 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A, L90M | L33F, K43T | L10I, K20R, E34N, E35D, M36I, N37S, R57K, D60DE, I62V, L63P, A71V, I93L | K70KAET |
| >3057-30407| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFNDISLPGRWTPKMIVGIGGFSKVKQYEQVP IEICGHTVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219N | K103N | T39A, K43KE, E44D, K64H, V118I, K122E, I135V, S162C, G196E, T200TA, E203K, Q207E, R211K, K223E, V245K |
| >3057-30407| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIHKKGSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGFYTP DNKHQEEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |