Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3151 | 3151-30815 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K219E | Y181C | D86E, S162C, Q174K, G196E, Q197K, R211A, L228H |
| >3151-30815| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQEFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKKNPDIVICQYMDDLYVGSDLEIEKHRTKIEELRQHLLAWGFTTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, V82VAIT, I84V | L10LF, Q58QE | I15V, K20R, E35D, M36I, N37D, K45KI, L63C |
| >3151-30815| codons 4-99 TLWQRPFVTIKVGGQLREALLDTGADDTILEDIDLPGRWKPIIVGGIGGFIKVREYDQIC IEICGHKAIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |