Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3150 | 3150-30610 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L33F, K43T, T74TP | L10I, I13V, K14R, L19Q, R41RK, L63T, A71V, V77I, I93L |
| >3150-30610| codons 4-99 TLWQRPIVTVRIGGQQKEALLDTGADDTVFEEMNLPGKWTPKLIVGIGGFSKVRQYDQIT IEICGHKVIGPVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C, G190A | K238T | K43E, E44A, V118I, T165I, G196R, R211N, V245E |
| >3150-30610| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVICQYMDDLYVASDLEIRQHRTKIEELRQHLWNWGFYTP DNKHQKEPPFLWMGYELHPDTWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |