Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3149 | 3149-30506 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10I, I15V, E35D, M36I, P39Q, R41K, D60E, I62V, L63P, I64V, A71V, I93L |
| >3149-30506| codons 4-99 TLWQRPIVTIKVGGQLKEALIDTGADDTVLEDINLQGKWKPKLIGGIGGFVKVRQYEQVP VEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115YF, M184V | Y181C | V179DE | S68N, D123E, I135R, T200TI, I202IV, R211AT, F214L |
| >3149-30506| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDNTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAFFSVPLDKEFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIEICQYVDDLYVGSDLEIGQHRIKVEELRQHLLTWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |