Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3148 | 3148-30506 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A | L33I, F53L, N83D | L10I, I13V, K14M, K20R, M36I, N37D, L63P, I64V, A71V, T91S |
| >3148-30506| codons 4-99 TLWQRPIVTVMIGGQLREALLDTGADDTIIEEIDLPGRWKPKIIGGIGGLVKVRQYDQIP VEICGHKVIGTVLVGPTPADIIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184MIV, T215F | K103N, Y181C | K104KR, K122E, I135V, I142T, E169D, G196R, T200A, H208Y, R211K, K223Q, L228R |
| >3148-30506| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNRSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIVICQYVDDLYVGSDLEIRQHRAKIEELRQYLLKWGFFTP DKKHQQEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |