Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3081 | 3081-30425 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L10F, L24I | K20R, M36I, N37ND, R41K, K43I, D60N, L63P, A71V |
| >3081-30425| codons 4-99 TLWQRPFVTIKIGGQLREALIDTGADDTVLEEIDLPGKWIPKIIGGIGGFVKVRQYNQIP IEICGHKVIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | S68G, T69I, K122E, I135V, S162C, I178IM, G196R |
| >3081-30425| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDGIKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSP AIFQCSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIRQHRTKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |