Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3077 | 3077-30403 | Canada | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10F, N88D | I13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64V |
| >3077-30403| codons 4-99 TLWQRPFVTVRIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYDQVQ VEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | E40D, K49R, V60I, D121Y, K122E, D177E, I178IM, T200TIM, E203EK, Q207E, R211K, V245K |
| >3077-30403| codons 38-247 CTDMEKEGKISRIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVIYQYVDDLYVGSDLEIGQHRMKIKELREHLLKWGFTTP DQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |