<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2308 2308-30716 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215F K219Q Y181C, G190A A98G, V179E T39TK, K43E, K64H, T69N, K103KR, V118I, K122E, D123N, S162D, D177E, I202V, H208Y, R211RK, D218E, L228H, V245VE  
>2308-30716| codons 38-247
CKELEEEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP
GGLKKRKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQDSMTKILEPFRKQNPEIEICQYMDDLYVASDLEIGQHRTKVEELRQYLLKWGFFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L10F, L33F, G73S E35ED, M36MIL, R41K, K55KR, R57K, I62V, L63P, A71V, I72L  
>2308-30716| codons 4-99
TLWQRPFVTIKIGGQLKEALLDTGADDTVFEDLNLPGKWKPKIIGGIGGFVRVKQYDQVP
IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006