Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2308 | 2308-30716 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, L33F, G73S | E35ED, M36MIL, R41K, K55KR, R57K, I62V, L63P, A71V, I72L |
| >2308-30716| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVFEDLNLPGKWKPKIIGGIGGFVRVKQYDQVP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219Q | Y181C, G190A | A98G, V179E | T39TK, K43E, K64H, T69N, K103KR, V118I, K122E, D123N, S162D, D177E, I202V, H208Y, R211RK, D218E, L228H, V245VE |
| >2308-30716| codons 38-247 CKELEEEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKRKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPEIEICQYMDDLYVASDLEIGQHRTKVEELRQYLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |