Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1298 | 1298-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, V82A, L90M | L10F, L33F, K43T | I13V, E35D, M36I, N37D, R57K, L63P, I64V, A71V, I93L |
| >1298-30623| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTVFEDIDLPGRWTPKIIGGIGGFMKVKQYDQIP VEICGHKVIGTVVVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y188L | T39A, E40F, K43E, V60I, V118I, I135V, Q174R, I178M, V179I, V189VI, I195L, G196E, T200A, E203K, Q207D, R211K, K223E, L228LH, V245T |
| >1298-30623| codons 38-247 CAFLEEEGKISKIGPENPYNTPIFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDMIIYQYVDDLLIGSDLELEQHRAKIKELRDHLWKWGFYTP DKKHQEEPPFHWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |