<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1296 1296-30507 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48L, I50V, I54V, V82A, L90M L33F L10V, E35D, M36I, I62V, L63P, A71V, I72V, I93L  
>1296-30507| codons 4-99
TLWQRPVVTIKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIILGVGGFVKVRQYDQVP
IEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, V75T, M184V, L210W, T215Y A62V, K219E Y181C, G190GS   E44D, K101Q, K102R, V118I, K122E, S162C, I178L, V179I, Q197E, D218E, L228H, V245VI  
>1296-30507| codons 38-247
CTELEKDGKISKIGPENPYNTPVFVIKKKNSTRWRKVTDFRELNKRTQDFWEVQLGIPHP
AGLQRKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKQNPDLIICQYVDDLYVSSDLEIGEHRTKIEELRQHLWRWGFYTP
EEKHQKEPPFHWMGYELHPDKWTVQPIILP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006