Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1296 | 1296-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48L, I50V, I54V, V82A, L90M | L33F | L10V, E35D, M36I, I62V, L63P, A71V, I72V, I93L |
| >1296-30507| codons 4-99 TLWQRPVVTIKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIILGVGGFVKVRQYDQVP IEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, V75T, M184V, L210W, T215Y | A62V, K219E | Y181C, G190GS | E44D, K101Q, K102R, V118I, K122E, S162C, I178L, V179I, Q197E, D218E, L228H, V245VI |
| >1296-30507| codons 38-247 CTELEKDGKISKIGPENPYNTPVFVIKKKNSTRWRKVTDFRELNKRTQDFWEVQLGIPHP AGLQRKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDLIICQYVDDLYVSSDLEIGEHRTKIEELRQHLWRWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |